January 31, 2023

 

Jefferies LLC

520 Madison Avenue

New York, New York 10022

 

SVB Securities LLC

53 State Street, 40th Floor

Boston, MA 02109

 

Guggenheim Securities, LLC

330 Madison Avenue

New York, New York 10017

 

BMO Capital Markets Corp.

151 W. 42nd Street, 31st Floor

New York, New York 10036

 

VIA EDGAR

 

U.S. Securities and Exchange Commission

Division of Corporation Finance

100 F Street, N.E.

Washington, D.C. 20549

 

Attn:

Vanessa Robertson

Terence O’Brien

Jimmy McNamara

Joe McCann

 

Re:

Structure Therapeutics Inc. Registration Statement on Form S-1

(File No. 333-269200)

 

Acceleration Request

	Requested Date:	February 2, 2023
	Requested Time:	4:00 P.M. Eastern Time

 

Ladies and Gentlemen:

 

In accordance with Rule 461 of the Securities Act of 1933, as amended (the “Securities Act”), we, as representatives of the several underwriters (the “Representatives”), hereby join in the request of Structure Therapeutics Inc., an exempted company with limited liability incorporated under the laws of the Cayman Islands (the “Registrant”), that the effectiveness of the above-captioned Registration Statement, as amended, be accelerated to 4:00 p.m. Eastern Time on February 2, 2023, or as soon thereafter as practicable, or at such other time as the Registrant or its outside counsel, Cooley LLP, request by telephone that such Registration Statement be declared effective.

 

Pursuant to Rule 460 under the Securities Act, please be advised that we will take reasonable steps to secure adequate distribution of the preliminary prospectus, to underwriters, dealers, institutions and others, prior to the requested effective time of the Registration Statement.

 

 

We, the undersigned Representatives, have and will, and we have been informed by the participating underwriters that they have and will, comply with the requirements of Rule 15c2-8 under the Securities Exchange Act of 1934, as amended, in connection with the proposed offering.

 

[Remainder of page intentionally left blank]

 

 

	Very truly yours,
	Acting severally on behalf of themselves and the several underwriters
	JEFFERIES LLC
	SVB SECURITIES LLC
	GUGGENHEIM SECURITIES, LLC
	BMO CAPITAL MARKETS CORP.
	JEFFERIES LLC
	By:	/s/ Bryan Czyzewski
	Name: Bryan Czyzewski
	Title: Managing Director
	SVB SECURITIES LLC
	By:	/s/ Dan Dubin
	Name: Dan Dubin
	Title: Vice Chairman, Global Co-Head of Healthcare Investment Banking
	GUGGENHEIM SECURITIES, LLC
	By:	/s/ Shiv Taylor M.D.
	Name: Shiv Taylor M.D.
	Title: Senior Managing Director
	BMO CAPITAL MARKETS CORP.
	By:	/s/ Marc Ogborn
	Name: Marc Ogborn
	Title: Managing Director

 

[Signature Page to Underwriters’ Acceleration Request Letter]