SEC Form 3

FORM 3

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person* FIL Ltd (Last) (First) (Middle) P.O. BOX H.M. 670 (Street) HAMILTON D0 00000 (City) (State) (Zip)	2. Date of Event Requiring Statement (Month/Day/Year) 02/02/2023	3. Issuer Name and Ticker or Trading Symbol Structure Therapeutics Inc. [ GPCR ]
		4. Relationship of Reporting Person(s) to Issuer (Check all applicable) Director X 10% Owner Officer (give title below) X Other (specify below) See Remark 1	5. If Amendment, Date of Original Filed (Month/Day/Year)
			6. Individual or Joint/Group Filing (Check Applicable Line) X Form filed by One Reporting Person Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Beneficially Owned
1. Title of Security (Instr. 4)	2. Amount of Securities Beneficially Owned (Instr. 4)	3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	4. Nature of Indirect Beneficial Ownership (Instr. 5)

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 4)	2. Date Exercisable and Expiration Date (Month/Day/Year)		3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)		4. Conversion or Exercise Price of Derivative Security	5. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Series A Convertible Preferred Shares	(1)	(1)	Ordinary Shares	4,013,678	(1)	I	Eight Roads Investments
Series A+ Convertible Preferred Shares	(1)	(1)	Ordinary Shares	620,499	(1)	I	Eight Roads Investments
Series B Convertible Preferred Shares	(1)	(1)	Ordinary Shares	452,867	(1)	I	Eight Roads Investments
Series B-1 Convertible Preferred Shares	(1)	(1)	Ordinary Shares	179,242	(1)	I	Eight Roads Investments
Series A Convertible Preferred Shares	(1)	(1)	Ordinary Shares	71,636	(1)	I	ERVC Healthcare Advisors IV, LP
Seriers A+ Convertible Preferred Shares	(1)	(1)	Ordinary Shares	10,154	(1)	I	ERVC Healthcare Advisors IV, LP
Series B Convertible Preferred Shares	(1)	(1)	Ordinary Shares	7,411	(1)	I	ERVC Healthcare Advisors IV, LP
Series B-1 Convertible Preferred Shares	(1)	(1)	Ordinary Shares	494,035	(1)	I	ERVC Healthcare V, LP
Series A Convertible Preferred Shares	(1)	(1)	Ordinary Shares	624,239	(1)	I	ERVC Healthcare IV, LP

Explanation of Responses:

1. The Series A+, A, B, and B-1 preferred shares are convertible on a 1-for-1 basis into the number of shares of Ordinary Shares as shown in column 3 at any time at the holder's election, and automatically upon the closing of the Issuer's initial public offering without payment or further consideration, and have no expiration date.

Remarks:

Remark 1:Eight Roads Shareholdings Limited ("ERSL") and Pandanus Partners, LP ("Pandanus") own shares of Eight Roads Holdings Limited ("ERHL") voting stock. ERHL is the immediate parent company of Eight Roads Investments ("ERI"), which owns the shares being reported on with this Form. While the percentage of total voting power represented by ERSL's and Pandanus' shares of ERHL voting stock may fluctuate due to changes in the total number of shares of ERHL voting stock outstanding from time to time, ERSL's holdings represents more than 50% and Pandanus' holding represents more than 25% and less than 50% of, the total votes which may be cast by all holders of ERHL voting stock. The shares in ERSL are owned primarily by officers and senior employees of FIL Limited and Eight Roads together with several charitable organizations. No such person or organization owns or controls more than 25% of the voting stock in ERSL. Pandanus Associates, Inc. ("PAI") acts as general partner of Pandanus. Pandanus is owned by trusts for the benefit of members of the Johnson family, including ERHL's Chairman Abigail P. Johnson, but disclaims that any such member is a beneficial owner of the securities reported on this form. The address of ERSL, ERHL and ERI is 42 Crow Lane, Hamilton HM19, Bermuda. The address of Pandanus is c/o FIL Limited, 42 Crow Lane, Hamilton HM19, Bermuda. The address of PAI is 11 Keewaydin Drive, Suite 100, Salem, NH, USA, 03079. ERVC Healthcare IV, LP and ERVC Healthcare V, LP (Collectively "ERVC HC") are limited partners. The General Partners of ERVC HC are ERVC Healthcare Advisors V, LP and ERVC Healthcare Advisors IV, LP (collectively "ERVC HCA"). The general partner of ERVC HCA is Eight Roads GP, which is controlled by ERSL. Remark 2: The filing of this statement shall not be deemed to be an admission that, for purposes of Section 16 of the Securities Exchange Act of 1934 or otherwise, the undersigned are the beneficial owners of any securities reported herein.

	Stephanie J. Brown, Duly authorized under Powers of Attorney, by and on behalf of FIL Limited, Eight Roads Shareholdings Limited, and its direct and indirect subsidiaries, Eight Roads Holdings Limited and Eight Roads Investments	02/02/2023
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 5 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.

Exhibit 24

POWER OF ATTORNEY

	Effective as of the date hereof, the undersigned does hereby appoint
Stephanie J. Brown, with full power of substitution, as the true and
lawful attorney of the undersigned, with full power and authority to
execute such documents and to make such regulatory or other filings
and amendments thereto as shall from time to time be required pursuant
to the Securities Exchange Act of 1934, as amended, any rules or
regulations adopted thereunder, and such other U.S. and non-U.S. laws,
rules or regulations as shall from time to time be applicable in respect
of the beneficial ownership of securities directly or indirectly
attributable to the undersigned, and generally to do all such things
in the name and on behalf of the undersigned in connection therewith
as said attorney-in-fact deems necessary or appropriate to cause such
 filings to be completed and filed.

	This Power of Attorney shall remain in full force and effect only for
such time as Stephanie J. Brown shall continue to be an officer of
Fidelity Management & Research Company LLC, provided that,
notwithstanding the foregoing, this Power of Attorney may be revoked
at any time by the undersigned in writing.

This Power of Attorney has been executed as of the 19th day of
December, 2022.

					Eight Roads Holding Limited
  					By /s/ Barclay Simmons
  					Barclay Simmons
  					Director

POWER OF ATTORNEY

	Effective as of the date hereof, the undersigned does hereby appoint
Stephanie J. Brown, with full power of substitution, as the true
and lawful attorney of the undersigned, with full power and authority to
execute such documents and to make such regulatory or other filings
and amendments thereto as shall from time to time be required pursuant
to the Securities Exchange Act of 1934, as amended, any rules or
regulations adopted thereunder, and such other U.S. and non-U.S. laws,
rules or regulations as shall from time to time be applicable in
respect of the beneficial ownership of securities directly or
indirectly attributable to the undersigned, and generally to do all
such things in the name and on behalf of the undersigned in connection
therewith as said attorney-in-fact deems necessary or appropriate
to cause such filings to be completed and filed.

	This Power of Attorney shall remain in full force and effect
only for such time as Stephanie J. Brown shall continue to be an officer
of Fidelity Management & Research Company LLC, provided that,
notwithstanding the foregoing, this Power of Attorney may be
revoked at any time by
the undersigned in writing.

	This Power of Attorney has been executed as of the 19th day
 of December, 2022.


						Eight Roads Investments
						By /s/ Driaan Viljoen
						Driaan Viljoen
						Director


POWER OF ATTORNEY

	Effective as of the date hereof, the undersigned does hereby appoint
Stephanie J. Brown, with full power of substitution, as the true
and lawful attorney of the undersigned, with full power and authority to
execute such documents and to make such regulatory or other filings
and amendments thereto as shall from time to time be required pursuant
to the Securities Exchange Act of 1934, as amended, any rules or
regulations adopted thereunder, and such other U.S. and non-U.S. laws,
rules or regulations as shall from time to time be applicable in
respect of the beneficial ownership of securities directly or
indirectly attributable to the undersigned, and generally to do all
such things in the name and on behalf of the undersigned in connection
therewith as said attorney-in-fact deems necessary or appropriate
to cause such filings to be completed and filed.

	This Power of Attorney shall remain in full force and effect
only for such time as Stephanie J. Brown shall continue to be an officer
of Fidelity Management & Research Company LLC, provided that,
notwithstanding the foregoing, this Power of Attorney may be
revoked at any time by
the undersigned in writing.

	This Power of Attorney has been executed as of the 19th day
 of December, 2022.

						Eight Roads Shareholdings Limited
						By /s/ Barclay Simmons
  						Barclay Simmons
  						Director